4:01 PM ET SANTA CLARA, Calif. — For the second week in a row, the San Francisco 49ers have lost their starting left tackle to injury for an extended period. A little more than a week after star left tackle Trent Williams suffered a high right ankle sprain in a Sept. 25 loss to the

11:46 AM ET The Denver Broncos signed veteran running back Latavius Murray off the New Orleans Saints‘ practice squad Tuesday and placed starting running back Javonte Williams and starting outside linebacker Randy Gregory on injured reserve. It’s unlikely that Murray will play Thursday night against the Indianapolis Colts, a source told ESPN, confirming multiple reports.

11:21 AM ET DJ Bien-AimeESPN The Houston Texans released starting tight end Pharaoh Brown, who led the team’s tight ends in catches (seven) and yards (72) on Tuesday. Brown started three games but missed the 34-24 Week 4 loss to the Los Angeles Chargers because of a hip and shoulder injury. The emergence of 2018

5:12 PM ET FRISCO, Texas — With Jake McQuaide suffering a torn triceps in last Sunday’s win against the Washington Commanders, the Dallas Cowboys are making their first in-season change at long snapper since 2005. The Cowboys added Matt Overton and Tucker Addington to the practice squad after workouts at The Star on Tuesday, according

11:16 AM ET Minnesota Vikings receiver Justin Jefferson did work in London on Sunday. In the 28-25 win over the New Orleans Saints at Tottenham Hotspur Stadium, Jefferson caught 10 passes for 147 yards. He also ran for a touchdown. It was the first time since 2016 that a player had 120 yards receiving and

6:45 AM ET NFL NationESPN Welcome to Week 5 of the NFL regular season. Our power panel — a group of more than 80 writers, editors and TV personalities — evaluated how teams are stacking up through four weeks and named a new No. 1 team for the second week in a row. The updated

2:00 PM ET Marcel Louis-JacquesESPN MIAMI — Dolphins quarterback Tua Tagovailoa has been ruled out for Sunday’s game against the New York Jets as he continues to progress through concussion protocol, coach Mike McDaniel said Monday. There’s no “definite timeline” for Tagovailoa’s return after he left the Dolphins’ 27-15 loss to the Cincinnati Bengals in

4:54 PM ET EAST RUTHERFORD, N.J. — New York Giants quarterback Daniel Jones has an ankle sprain and showed some signs of improvement on Monday, coach Brian Daboll said. Whether he’ll be able to play Sunday against the Green Bay Packers in London remains in doubt. “Daniel is feeling a little bit better today,” Daboll

1:06 PM ET ENGLEWOOD, Colo. — The Denver Broncos‘ loss to the Las Vegas Raiders on Sunday came with a staggering price tag as running back Javonte Williams will miss the remainder of the season with a right knee injury and outside linebacker Randy Gregory will miss multiple weeks with a right knee injury. Coach

7:37 PM ET Washington Commanders coach Ron Rivera, in Year No. 3 of his tenure, said Monday if anyone thought it would be easy to turn around an organization with one playoff win since 2005, “they’re crazy.” “It’s going to take time,” Rivera said. But, having lost three consecutive games to fall to 1-3 —